Separate evidence layers
PK/PD, clinical events, reporting signals and patient experience remain distinct.
FREEZES · DISCRIMINATORS · BOUNDARIES
The method protects the difference between signal and conclusion.
The audit asks not only whether a difference exists, but whether the evidence can determine which relation produced it.
Preserve time
Baseline, exposure, dose change, transition and new stable state must not collapse.
Require discriminators
Alternative explanations need measures, comparators and follow-up capable of separating them.
Abstain when needed
Missing data must remain a data gap. Absence of significance is not demonstrated equality.
Structure of the material
Ten medicine groups
SSRIs, Z-drugs, NSAIDs, ADHD, statins, blood pressure, metabolic treatment, opioids, PPIs and thyroid.
Portfolio and findings register
Priorities, evidence layers, repeated data gaps, mechanisms and what was not measured.
Three discriminator paths
Standard dose/exposure, proxy/function/recoverability and discontinuation/rebound/false anchors.
IMPORTANT BOUNDARY
Not treatment or discontinuation guidance
The material supports research, method critique and hypothesis generation. It cannot determine what an individual should take, change or stop. Medication changes should be discussed with the relevant healthcare professional.