Standard dose can hide different internal exposure
The same prescribed dose does not establish the same concentration, time profile or burden. Sex is often recorded and then left as a residual category.
ACROSS TEN GATES
The strongest pattern is not one difference. It is what was not preserved.
The audit identifies repeated breaks between recording sex and actually analysing exposure, life stage, function, transition and recoverability.
Proxy outcomes can eclipse lived function
Biomarkers and symptom scores are not identical to access to sleep, movement, participation or stable function.
Transition can be misread as disease
Withdrawal, rebound, relapse, treatment-created state and removed support must be measured separately.
A female majority is not female-specific evidence
Cycle, pregnancy, postpartum and menopause often disappear between inclusion and conclusion.
Timing is information, not proof of mechanism
Dense time measurement can help distinguish phenomena, but sequence alone does not identify cause.
A normal value is not necessarily a path back
Robustness requires follow-up of which viable next states are actually accessible.
WHAT THE AUDIT DOES NOT SHOW
It does not show that all women respond alike.
Nor does it show that every reported difference is biological, or that medicine is generally wrong. It shows where evidence design cannot distinguish plausible explanations and which relations future research must preserve.